ITM2C

Across TCGA patient cohorts, ITM2C mutation is significantly associated with the RNA expression of many other genes, with 1,354 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITM2C-associated genes across cancer lineages are MYO9B, MIR6815, and RNU7-29P. Each is linked with ITM2C in more than 1 cancer types. Because this analysis shows association rather than direction, both ITM2C-to-partner and partner-to-ITM2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYO9B grouped by ITM2C-low versus ITM2C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITM2C→partner) and Y-score (partner→ITM2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYO9B →	+0.435	+3.743	.002	<.001	3	2
SKCM	MIR6815 →	+0.207	+4.212	<.001	.007	3	2
UCEC	RNU7-29P →	+0.178	+3.219	<.001	.004	3	2
UCEC	DPP9 →	+0.437	+2.534	<.001	.001	3	2
HNSC	LINC00254 →	+0.087	+5.736	<.001	.003	3	1
UCEC	PGAP2 →	+0.405	+2.716	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,354 associations by consensus.

MYO9B by ITM2C expression — UCEC

Explore this box plot interactively →