ITM2C

Across TCGA pan-cancer cohorts, ITM2C RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ITM2C data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ITM2C RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ITM2C expression acts as an unfavorable survival marker, although some lineages such as KIRC and PAAD show a favorable association.

ACC, UVM, and KIRP are the cancer types where ITM2C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.211	0.663	<.001	142	view →
UVM	DFS	Median	All	0.414	0.763	<.001	121	view →
KIRP	OS	Tertile	III,IV	0.176	0.683	.004	66	view →
KIRC	DFS	Quartile	All	0.728	0.519	.002	48	view →
LUSC	OS	Tertile	II,III,IV	0.500	0.743	.003	38	view →
MESO	DFS	Median	II,III,IV	0.203	0.698	<.001	36	view →
LGG	OS	Tertile	All	0.731	0.868	<.001	29	view →
UCEC	DFS	Quartile	All	0.465	0.682	.003	22	view →
SKCM	DFS	Tertile	II,III,IV	0.610	0.748	.011	21	view →
LUAD	DFS	Tertile	All	0.180	0.509	.002	14	view →
PAAD	OS	Quartile	II,III,IV	0.617	0.375	.005	12	view →
BRCA	DFS	Median	All	0.600	0.457	.004	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ITM2C–ACC (DFS)

Open the ACC breakdown →