ITM2C

Across TCGA patient cohorts, ITM2C mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITM2C-associated genes across cancer lineages are eIF4E, FoxM1, and GAPDH. Each is linked with ITM2C in more than 1 cancer types. Because this analysis shows association rather than direction, both ITM2C-to-partner and partner-to-ITM2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ITM2C-low versus ITM2C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITM2C→partner) and Y-score (partner→ITM2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.187	+3.013	.031	.018	3	1
UCEC	FoxM1 →	+0.266	+2.321	.012	.006	3	1
UCEC	GAPDH →	+0.512	+3.169	.020	.018	3	1
UCEC	JNK2 →	+0.299	+2.321	<.001	.006	3	1
UCEC	Ku80 →	+0.270	+1.750	.005	.049	3	1
UCEC	mTOR_pS2448 →	-0.143	-2.308	.020	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

eIF4E by ITM2C expression — UCEC

Explore this box plot interactively →