ITM2C

Across TCGA cell cohorts, ITM2C RNA expression is significantly associated with the go_rna of many other GO terms, with 4,822 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ITM2C-associated GO terms across cancer lineages are Regulation of myoblast fusion, Negative regulation of myoblast fusion, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with ITM2C in more than 15 cancer types. Because this analysis shows association rather than direction, both ITM2C-to-partner and partner-to-ITM2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of myoblast fusion grouped by ITM2C-low versus ITM2C-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITM2C→partner) and Y-score (partner→ITM2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.115	+1.475	<.001	.002	3	15
STOMACH	Negative regulation of myoblast fusion →	+0.110	+2.288	.005	<.001	2	16
STOMACH	Negative regulation of syncytium formation by plasma membrane fusion →	+0.110	+2.288	.005	<.001	2	15
UPPER_AERODIGESTIVE_TRACT	Regulation of syncytium formation by plasma membrane fusion →	+0.113	+1.950	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Aerobic respiration →	+0.091	+1.546	.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Cellular respiration →	+0.085	+1.520	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,822 associations by consensus.

Regulation of myoblast fusion by ITM2C expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →