ITM2C

Across TCGA cell cohorts, ITM2C mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ITM2C-associated genes across cancer lineages are OR10W1, GPR101, and OXGR1. Each is linked with ITM2C in more than 1 cancer types. Because this analysis shows association rather than direction, both ITM2C-to-partner and partner-to-ITM2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10W1 grouped by ITM2C-low versus ITM2C-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITM2C→partner) and Y-score (partner→ITM2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10W1 →	+0.022	+4.977	<.001	.007	3	1
BLOOD_Leukemia	GPR101 →	+0.106	+3.551	<.001	.009	3	1
BLOOD_Leukemia	OXGR1 →	+0.123	+3.847	<.001	.007	3	1
BLOOD_Leukemia	OR13J1 →	+0.168	+3.774	<.001	.008	3	1
BLOOD_Leukemia	RGS7 →	+0.327	+3.769	<.001	.008	3	1
BLOOD_Leukemia	IFNA1 →	+0.142	+4.269	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR10W1 by ITM2C expression — LARGE_INTESTINE

Explore this box plot interactively →