ITM2B

Across TCGA patient cohorts, ITM2B protein abundance is significantly associated with the RNA expression of many other genes, with 11,066 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ITM2B-associated genes across cancer lineages are RNF6, SUCLA2, and MCM3. Each is linked with ITM2B in more than 3 cancer types. Because this analysis shows association rather than direction, both ITM2B-to-partner and partner-to-ITM2B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ITM2B versus RNF6 in LSCC, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITM2B→partner) and Y-score (partner→ITM2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RNF6 →	+0.455	+0.372	<.001	<.001	3	4
OV	SUCLA2 →	+0.566	+0.510	<.001	<.001	3	4
UCEC	MCM3 →	-0.775	-0.411	.001	<.001	3	4
CCRCC	PLEKHB2 →	+0.391	+0.214	<.001	.001	3	4
GBM	CENPF →	-1.005	-0.357	<.001	.001	3	4
GBM	TOP2A →	-1.068	-0.293	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,066 associations by consensus.

ITM2B vs RNF6 — LSCC

Explore this scatter interactively →