ITM2A

Across TCGA patient cohorts, ITM2A protein abundance is significantly associated with the RNA expression of many other genes, with 2,426 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ITM2A-associated genes across cancer lineages are RAMP2, HSPA12B, and SLC39A12. Each is linked with ITM2A in more than 1 cancer types. Because this analysis shows association rather than direction, both ITM2A-to-partner and partner-to-ITM2A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ITM2A versus RAMP2 in CCRCC, with a Pearson correlation of 0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITM2A→partner) and Y-score (partner→ITM2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RAMP2 →	+0.909	+0.447	<.001	.001	3	2
CCRCC	HSPA12B →	+0.827	+0.405	.002	.005	3	2
GBM	SLC39A12 →	+1.058	+0.548	<.001	<.001	3	2
CCRCC	CLEC14A →	+0.946	+0.405	.002	.005	3	2
GBM	CLDN5 →	+1.253	+0.483	<.001	<.001	3	2
GBM	RPL7L1P4 →	+0.479	+0.613	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,426 associations by consensus.

ITM2A vs RAMP2 — CCRCC

Explore this scatter interactively →