ITM2A

Across TCGA pan-cancer cohorts, ITM2A RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ITM2A’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where ITM2A RNA is repressed in tumor relative to normal tissue. In most cancer types ITM2A is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and HNSC are the cancer types where ITM2A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITM2A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−3.950	<.001	12	view →
COAD	All	IV	−2.481	<.001	11	view →
HNSC	Male	All	−2.432	<.001	11	view →
THCA	Male	III,IV	−2.598	<.001	10	view →
LUSC	All	III,IV	−2.961	<.001	9	view →
LUAD	Female	III,IV	−2.892	<.001	9	view →
KICH	Male	II,III,IV	−2.578	<.001	9	view →
KIRP	Male	All	−1.860	<.001	9	view →
UCEC	All	All	−4.791	<.001	8	view →
BRCA	All	II,III,IV	−2.642	<.001	6	view →
READ	All	All	−2.507	<.001	5	view →
STAD	All	All	−0.847	.004	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ITM2A–BLCA

Open the BLCA breakdown →