ITM2A

Across TCGA patient cohorts, ITM2A mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITM2A-associated genes across cancer lineages are eEF2, VHL, and EGFR_pY1068. Each is linked with ITM2A in more than 1 cancer types. Because this analysis shows association rather than direction, both ITM2A-to-partner and partner-to-ITM2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ITM2A-low versus ITM2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITM2A→partner) and Y-score (partner→ITM2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.285	+1.247	.019	.045	3	2
UCEC	VHL →	-0.692	-1.514	.002	.015	3	2
UCEC	EGFR_pY1068 →	-0.271	-2.169	.001	.003	3	1
UCEC	eIF4E →	+0.159	+3.000	.027	<.001	3	1
UCEC	A-Raf_pS299 →	-0.117	-1.247	.004	.045	3	1
UCEC	ERK2 →	+0.218	+3.700	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

eEF2 by ITM2A expression — UCEC

Explore this box plot interactively →