ITIH6

Across TCGA patient cohorts, ITIH6 protein abundance is significantly associated with the RNA expression of many other genes, with 93 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible ITIH6-associated genes across cancer lineages are KLF8, NUDT10, and MED13L. Each is linked with ITIH6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITIH6-to-partner and partner-to-ITIH6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ITIH6 versus KLF8 in HNSC, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITIH6→partner) and Y-score (partner→ITIH6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	KLF8 →	+1.406	+0.855	.007	.004	3	1
HNSC	NUDT10 →	+1.866	+0.516	.001	.004	3	1
HNSC	MED13L →	+0.444	+0.532	.002	.007	3	1
HNSC	LYST →	+0.834	+0.591	.002	.002	3	1
HNSC	PLA2R1 →	+1.213	+0.714	.002	.009	3	1
HNSC	RHBDL2 →	+1.234	+0.638	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 93 associations by consensus.

ITIH6 vs KLF8 — HNSC

Explore this scatter interactively →