ITIH6

Across TCGA pan-cancer cohorts, ITIH6 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ITIH6 data layer compared with 8 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ITIH6 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ITIH6 expression acts as an unfavorable survival marker, although some lineages such as SCLC and LUSC show a favorable association.

UVM, KIRC, and SCLC are the cancer types where ITIH6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.412	0.777	<.001	125	view →
KIRC	OS	Tertile	All	0.499	0.665	<.001	101	view →
SCLC	DFS	Median	II,III,IV	0.812	0.286	<.001	86	view →
COAD	OS	Tertile	All	0.734	0.874	.001	79	view →
LGG	DFS	Tertile	All	0.240	0.427	<.001	35	view →
ACC	DFS	Median	All	0.303	0.636	.041	26	view →
LUSC	DFS	Quartile	II,III,IV	0.783	0.620	.009	25	view →
SKCM	OS	Quartile	All	0.445	0.263	.005	24	view →
UCEC	DFS	Median	All	0.861	0.920	.006	22	view →
LIHC	OS	Tertile	All	0.680	0.799	.007	21	view →
KIRP	DFS	Tertile	All	0.413	0.644	.002	18	view →
PRAD	DFS	Tertile	All	0.871	0.677	.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ITIH6–UVM (OS)

Open the UVM breakdown →