ITIH6

Across TCGA patient cohorts, ITIH6 mutation is significantly associated with the RNA expression of many other genes, with 5,133 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITIH6-associated genes across cancer lineages are MTFR2, NOLC1, and CTBP2P10. Each is linked with ITIH6 in more than 3 cancer types. Because this analysis shows association rather than direction, both ITIH6-to-partner and partner-to-ITIH6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTFR2 grouped by ITIH6-low versus ITIH6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITIH6→partner) and Y-score (partner→ITIH6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MTFR2 →	+0.556	+2.082	.001	.005	3	4
UCEC	NOLC1 →	+0.401	+1.800	<.001	<.001	3	4
COAD	CTBP2P10 →	+0.005	+4.741	<.001	.001	3	4
UCEC	PGP →	+0.412	+2.064	<.001	<.001	3	4
CESC	NPM1P28 →	+0.033	+3.269	.001	.009	3	3
SKCM	ATP1B2 →	-1.719	-3.662	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,133 associations by consensus.

MTFR2 by ITIH6 expression — SKCM

Explore this box plot interactively →