ITIH6

Across TCGA patient cohorts, ITIH6 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITIH6-associated genes across cancer lineages are 4E-BP1, JNK_pT183_Y185, and ATM. Each is linked with ITIH6 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITIH6-to-partner and partner-to-ITIH6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ITIH6-low versus ITIH6-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITIH6→partner) and Y-score (partner→ITIH6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.353	+3.321	.012	.010	3	3
UCEC	JNK_pT183_Y185 →	-0.139	-1.489	.002	<.001	3	3
UCEC	ATM →	-0.435	-1.669	<.001	<.001	3	3
LUAD	p70-S6K →	+0.186	+2.700	.012	.005	3	2
LUSC	ACC_pS79 →	-0.341	-3.450	.030	.005	3	2
STAD	XRCC1 →	+0.182	+3.321	.044	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

4E-BP1 by ITIH6 expression — STAD

Explore this box plot interactively →