ITIH6

Across TCGA cell cohorts, ITIH6 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,151 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ITIH6-associated GO terms across cancer lineages are Regulation of mRNA splicing, via spliceosome, Vacuolar transport, and Promoter clearance during DNA-templated transcription. Each is linked with ITIH6 in more than 6 cancer types. Because this analysis shows association rather than direction, both ITIH6-to-partner and partner-to-ITIH6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mRNA splicing, via spliceosome grouped by ITIH6-low versus ITIH6-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITIH6→partner) and Y-score (partner→ITIH6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Regulation of mRNA splicing, via spliceosome →	+0.047	+0.007	<.001	.001	3	7
OVARY	Vacuolar transport →	+0.050	+0.084	.002	.003	3	6
BLOOD_Leukemia	Promoter clearance during DNA-templated transcription →	+0.069	+0.008	<.001	<.001	3	6
BLOOD_Leukemia	RNA polymerase II promoter clearance →	+0.069	+0.008	<.001	<.001	3	6
BREAST	Extracellular matrix organization →	-0.084	-0.922	<.001	<.001	3	6
BLOOD_Leukemia	Regulation of DNA-templated transcription elongation →	+0.034	+0.007	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,151 associations by consensus.

Regulation of mRNA splicing, via spliceosome by ITIH6 expression — BLOOD_Leukemia

Explore this box plot interactively →