ITIH6

Across TCGA cell cohorts, ITIH6 mutation is significantly associated with the RNA expression of many other genes, with 176 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITIH6-associated genes across cancer lineages are GAGE12E, KLHL40, and FAM47A. Each is linked with ITIH6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITIH6-to-partner and partner-to-ITIH6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE12E grouped by ITIH6-low versus ITIH6-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITIH6→partner) and Y-score (partner→ITIH6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GAGE12E →	+1.043	+3.459	<.001	.003	3	2
BREAST	KLHL40 →	+0.014	+4.421	<.001	.004	3	2
BLOOD_Lymphoma	FAM47A →	+0.026	+4.867	<.001	.009	3	2
SOFT_TISSUE	CD40LG →	+0.038	+4.222	<.001	.007	3	1
SOFT_TISSUE	C16orf78 →	+0.024	+4.369	<.001	.008	3	1
SOFT_TISSUE	VPREB1 →	+0.063	+4.222	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 176 associations by consensus.

GAGE12E by ITIH6 expression — LUNG_SCLC

Explore this box plot interactively →