ITIH5

Across TCGA pan-cancer cohorts, ITIH5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ITIH5 data layer compared with 21 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ITIH5 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ITIH5 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where ITIH5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.906	1.000	.004	28	view →
LUAD	DFS	Quartile	III,IV	0.235	0.854	.010	12	view →
CCRCC	OS	Quartile	III,IV	0.855	0.420	.030	7	view →
PDAC	OS	Tertile	IV	0.905	0.231	.024	5	view →
LSCC	DFS	Median	II,III,IV	0.834	1.000	.005	5	view →
GBM	DFS	Median	All	0.792	0.645	.017	5	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ITIH5–HNSC (OS)

Open the HNSC breakdown →