ITIH5

Across TCGA patient cohorts, ITIH5 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITIH5-associated genes across cancer lineages are ATM, Shc_pY317, and PCNA. Each is linked with ITIH5 in more than 4 cancer types. Because this analysis shows association rather than direction, both ITIH5-to-partner and partner-to-ITIH5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ITIH5-low versus ITIH5-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITIH5→partner) and Y-score (partner→ITIH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ATM →	-0.524	-3.000	.002	.033	3	5
LUAD	Shc_pY317 →	-0.209	-3.321	.004	.010	3	3
COAD	PCNA →	+0.202	+2.182	.038	.033	3	3
COAD	Caspase-7-cleavedD198 →	+1.152	+2.123	<.001	.010	3	3
LUSC	PI3K-p85 →	-0.198	-2.312	.005	.035	3	2
COAD	p90 RSK_pT359_S363 →	-0.176	-3.169	.012	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

ATM by ITIH5 expression — STAD

Explore this box plot interactively →