ITIH5

Across TCGA cell cohorts, ITIH5 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,729 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ITIH5-associated GO terms across cancer lineages are Response to endoplasmic reticulum stress, Response to hydrostatic pressure, and Negative regulation of myoblast fusion. Each is linked with ITIH5 in more than 6 cancer types. Because this analysis shows association rather than direction, both ITIH5-to-partner and partner-to-ITIH5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to endoplasmic reticulum stress grouped by ITIH5-low versus ITIH5-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITIH5→partner) and Y-score (partner→ITIH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Response to endoplasmic reticulum stress →	+0.038	+1.795	.005	.005	3	6
SKIN	Response to hydrostatic pressure →	+0.174	+3.173	<.001	.002	3	6
SKIN	Negative regulation of myoblast fusion →	+0.075	+2.610	<.001	.004	3	6
SKIN	Negative regulation of syncytium formation by plasma membrane fusion →	+0.077	+2.829	<.001	.002	3	6
OVARY	Import across plasma membrane →	-0.049	-2.083	<.001	<.001	2	7
BONE	Protein targeting →	+0.045	+0.948	<.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,729 associations by consensus.

Response to endoplasmic reticulum stress by ITIH5 expression — KIDNEY

Explore this box plot interactively →