ITIH4-AS1

Across TCGA pan-cancer cohorts, ITIH4-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ITIH4-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ITIH4-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ITIH4-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LUAD show a favorable association.

KIRC, SKCM, and LGG are the cancer types where ITIH4-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	II,III,IV	0.397	0.619	<.001	85	view →
SKCM	OS	Median	All	0.845	0.749	.001	57	view →
LGG	DFS	Median	All	0.671	0.803	<.001	50	view →
LUAD	OS	Median	All	0.466	0.286	.001	40	view →
ACC	DFS	Tertile	All	0.468	0.701	.013	33	view →
CHOL	DFS	Median	II,III,IV	0.121	0.626	.002	23	view →
DLBC	OS	Tertile	II,III,IV	0.777	1.000	.014	21	view →
READ	DFS	Tertile	IV	0.179	0.936	.010	21	view →
PRAD	DFS	Quartile	All	0.880	0.949	.003	18	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	18	view →
KIRP	DFS	Tertile	III,IV	0.895	0.623	.021	18	view →
ESCA	DFS	Quartile	III,IV	0.476	0.230	.023	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ITIH4-AS1–KIRC (OS)

Open the KIRC breakdown →