ITIH4-AS1

Across TCGA pan-cancer cohorts, ITIH4-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ITIH4-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where ITIH4-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ITIH4-AS1 is over-expressed in tumor, although a few such as BRCA and LUAD show the opposite, repressed pattern.

BRCA, LUAD, and LUSC are the cancer types where ITIH4-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITIH4-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	−0.202	<.001	6	view →
LUAD	All	II,III,IV	−0.200	.003	5	view →
LUSC	Female	II,III,IV	−0.311	<.001	4	view →
THCA	All	All	−0.090	.009	4	view →
KIRC	Male	All	+0.086	.003	3	view →
CHOL	All	All	−0.946	.004	2	view →
BLCA	Female	All	+0.260	.025	2	view →
KIRP	Female	II,III,IV	+0.186	.034	2	view →
READ	All	All	−0.145	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ITIH4-AS1–BRCA

Open the BRCA breakdown →