ITIH3

Across TCGA pan-cancer cohorts, ITIH3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ITIH3 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ITIH3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ITIH3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LSCC, UCEC, and CCRCC are the cancer types where ITIH3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.867	1.000	.002	27	view →
UCEC	OS	Tertile	All	0.873	1.000	.012	22	view →
CCRCC	DFS	Tertile	IV	1.000	0.216	.024	14	view →
LUAD	OS	Quartile	III,IV	0.197	0.840	.005	11	view →
PDAC	OS	Median	All	0.378	0.589	.016	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ITIH3–LSCC (DFS)

Open the LSCC breakdown →