ITIH3

Across TCGA pan-cancer cohorts, ITIH3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ITIH3’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ITIH3 RNA is repressed in tumor relative to normal tissue. In most cancer types ITIH3 is over-expressed in tumor, although a few such as LUAD and THCA show the opposite, repressed pattern.

LUAD, THCA, and LUSC are the cancer types where ITIH3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITIH3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−1.210	<.001	11	view →
THCA	All	III,IV	−0.617	<.001	11	view →
LUSC	Male	II,III,IV	−1.385	<.001	8	view →
UCEC	All	All	−1.018	<.001	6	view →
BRCA	Female	All	−0.467	<.001	6	view →
BLCA	Male	All	−0.512	.008	4	view →
CHOL	All	All	−4.702	<.001	3	view →
HNSC	Female	IV	+0.458	.026	2	view →
KIRP	Female	All	−0.399	.012	2	view →
KIRC	All	All	+0.370	.004	2	view →
PRAD	All	All	−0.159	.011	2	view →
STAD	Female	III,IV	+1.050	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ITIH3–LUAD

Open the LUAD breakdown →