ITIH3

Across TCGA patient cohorts, ITIH3 mutation is significantly associated with the RNA expression of many other genes, with 2,758 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITIH3-associated genes across cancer lineages are RNU6-541P, MBOAT4, and AP3S1. Each is linked with ITIH3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITIH3-to-partner and partner-to-ITIH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-541P grouped by ITIH3-low versus ITIH3-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITIH3→partner) and Y-score (partner→ITIH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RNU6-541P →	+0.520	+5.925	<.001	.002	3	3
UCEC	MBOAT4 →	+0.205	+2.857	<.001	<.001	3	3
UCEC	AP3S1 →	+0.459	+2.917	.001	<.001	3	3
UCEC	SGSM3 →	+0.395	+2.010	.001	<.001	3	3
UCEC	PPP2CB →	+0.602	+2.671	<.001	<.001	3	3
UCEC	ASAH1 →	+0.399	+2.823	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,758 associations by consensus.

RNU6-541P by ITIH3 expression — READ

Explore this box plot interactively →