ITIH3

Across TCGA cell cohorts, ITIH3 mutation is significantly associated with the RNA expression of many other genes, with 206 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITIH3-associated genes across cancer lineages are SUPT20HL1, CCDC182, and CELA2B. Each is linked with ITIH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITIH3-to-partner and partner-to-ITIH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SUPT20HL1 grouped by ITIH3-low versus ITIH3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITIH3→partner) and Y-score (partner→ITIH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SUPT20HL1 →	+0.107	+3.556	<.001	.001	3	2
OESOPHAGUS	CCDC182 →	+0.034	+4.392	<.001	.003	3	1
OESOPHAGUS	CELA2B →	+0.090	+4.392	<.001	.003	3	1
SOFT_TISSUE	H2BC1 →	+0.260	+4.392	<.001	.004	3	1
SOFT_TISSUE	H2AC1 →	+0.115	+4.392	<.001	.004	3	1
SOFT_TISSUE	OR2M4 →	+0.071	+3.865	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 206 associations by consensus.

SUPT20HL1 by ITIH3 expression — BLOOD_Leukemia

Explore this box plot interactively →