ITIH2

Across TCGA cell cohorts, ITIH2 mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ITIH2-associated genes across cancer lineages are SPINK8, HES3, and OR2B3. Each is linked with ITIH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITIH2-to-partner and partner-to-ITIH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPINK8 grouped by ITIH2-low versus ITIH2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITIH2→partner) and Y-score (partner→ITIH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SPINK8 →	+0.305	+4.266	<.001	.001	3	2
LUNG_NSCLC_LUAD	HES3 →	+0.051	+4.628	.003	.001	3	2
LUNG_SCLC	OR2B3 →	+0.014	+4.058	<.001	.007	3	2
LUNG_NSCLC_LUSC	ADGRE3 →	+0.028	+3.584	<.001	.003	3	1
LUNG_NSCLC_LUSC	C13orf42 →	+0.030	+3.754	<.001	.009	3	1
OVARY	SCGB1D4 →	+0.078	+4.222	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

SPINK8 by ITIH2 expression — BLOOD_Leukemia

Explore this box plot interactively →