ITGB6

Across TCGA patient cohorts, ITGB6 mutation is significantly associated with the RNA expression of many other genes, with 3,118 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGB6-associated genes across cancer lineages are BUB3, PTTG1, and ZFYVE19. Each is linked with ITGB6 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITGB6-to-partner and partner-to-ITGB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB3 grouped by ITGB6-low versus ITGB6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB6→partner) and Y-score (partner→ITGB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB3 →	+0.481	+2.882	<.001	.001	3	3
UCEC	PTTG1 →	+0.634	+2.000	.004	.003	3	3
SKCM	ZFYVE19 →	+0.467	+4.292	<.001	<.001	3	3
UCEC	CHAF1A →	+0.755	+2.413	<.001	<.001	3	3
UCEC	STIP1 →	+0.585	+2.874	<.001	<.001	3	3
UCEC	FEN1 →	+0.654	+2.424	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,118 associations by consensus.

BUB3 by ITGB6 expression — UCEC

Explore this box plot interactively →