ITGB6

Across TCGA pan-cancer cohorts, ITGB6 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ITGB6 data layer compared with 11 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher ITGB6 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ITGB6 expression acts as an unfavorable survival marker, although some lineages such as BLCA and LGG show a favorable association.

PAAD, LUSC, and LIHC are the cancer types where ITGB6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	OS	Tertile	All	0.210	0.566	<.001	89	view →
LUSC	DFS	Median	All	0.295	0.457	.001	52	view →
LIHC	OS	Quartile	All	0.338	0.628	.001	41	view →
BLCA	DFS	Median	III,IV	0.420	0.197	.001	38	view →
STAD	OS	Median	III,IV	0.520	0.723	.005	28	view →
SKCM	OS	Quartile	II,III,IV	0.551	0.800	<.001	27	view →
UVM	DFS	Median	III,IV	0.293	0.763	.013	21	view →
MESO	OS	Quartile	II,III,IV	0.420	0.722	.005	17	view →
KIRC	DFS	Quartile	All	0.717	0.838	.020	14	view →
LGG	OS	Quartile	All	0.651	0.433	.008	11	view →
ESCA	DFS	Median	III,IV	0.561	0.331	.007	11	view →
ACC	OS	Median	IV	0.355	0.692	.018	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ITGB6–PAAD (OS)

Open the PAAD breakdown →