ITGB6

Across TCGA patient cohorts, ITGB6 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGB6-associated genes across cancer lineages are Cyclin-B1, Caspase-7-cleavedD198, and FoxM1. Each is linked with ITGB6 in more than 3 cancer types. Because this analysis shows association rather than direction, both ITGB6-to-partner and partner-to-ITGB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ITGB6-low versus ITGB6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB6→partner) and Y-score (partner→ITGB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.707	+3.700	<.001	.001	3	4
COAD	Caspase-7-cleavedD198 →	+0.821	+2.824	.027	.034	3	3
UCEC	FoxM1 →	+0.260	+2.247	.006	.001	3	3
UCEC	Ku80 →	+0.272	+2.261	.001	.001	3	3
UCEC	NDRG1_pT346 →	-0.409	-2.321	.023	.033	3	3
UCEC	TFRC →	+0.390	+2.000	.045	.029	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Cyclin-B1 by ITGB6 expression — UCEC

Explore this box plot interactively →