ITGB6

Across TCGA cell cohorts, ITGB6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,990 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ITGB6-associated GO terms across cancer lineages are Positive regulation of sodium ion transmembrane transport, Intracellular sodium ion homeostasis, and Small GTPase-mediated signal transduction. Each is linked with ITGB6 in more than 12 cancer types. Because this analysis shows association rather than direction, both ITGB6-to-partner and partner-to-ITGB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of sodium ion transmembrane transport grouped by ITGB6-low versus ITGB6-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB6→partner) and Y-score (partner→ITGB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of sodium ion transmembrane transport →	+0.185	+2.462	<.001	<.001	3	13
STOMACH	Intracellular sodium ion homeostasis →	+0.240	+1.768	.001	<.001	3	13
STOMACH	Small GTPase-mediated signal transduction →	+0.068	+2.403	<.001	<.001	3	13
PANCREAS	Regulation of actin filament polymerization →	+0.092	+2.606	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Maintenance of blood-brain barrier →	+0.179	+2.151	<.001	<.001	3	12
PANCREAS	Cell-cell junction organization →	+0.081	+1.874	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,990 associations by consensus.

Positive regulation of sodium ion transmembrane transport by ITGB6 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →