ITGB6

Across TCGA cell cohorts, ITGB6 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITGB6-associated genes across cancer lineages are DRD1, KRTAP3-2, and FKBP6. Each is linked with ITGB6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITGB6-to-partner and partner-to-ITGB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DRD1 grouped by ITGB6-low versus ITGB6-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB6→partner) and Y-score (partner→ITGB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DRD1 →	+0.141	+4.192	<.001	.003	3	1
BLOOD_Lymphoma	KRTAP3-2 →	+0.050	+4.662	<.001	.003	3	1
BLOOD_Lymphoma	FKBP6 →	+0.055	+4.321	<.001	.002	3	1
SKIN	SSTR4 →	+0.035	+4.347	.003	.001	3	1
SKIN	GC →	+0.077	+4.054	<.001	.004	3	1
BLOOD_Leukemia	PHOX2B →	+0.019	+4.365	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

DRD1 by ITGB6 expression — BLOOD_Lymphoma

Explore this box plot interactively →