ITGB5

Across TCGA patient cohorts, ITGB5 mutation is significantly associated with the RNA expression of many other genes, with 973 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGB5-associated genes across cancer lineages are RAP1BL, MIR3973, and MIR5707. Each is linked with ITGB5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITGB5-to-partner and partner-to-ITGB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAP1BL grouped by ITGB5-low versus ITGB5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB5→partner) and Y-score (partner→ITGB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RAP1BL →	+0.532	+3.507	.003	.002	3	2
SKCM	MIR3973 →	+0.100	+3.054	<.001	.006	3	2
UCEC	MIR5707 →	+0.170	+2.384	<.001	.007	3	2
UCEC	KCTD9 →	+0.537	+2.617	.001	<.001	3	2
UCEC	KXD1 →	+0.362	+1.970	<.001	<.001	3	2
UCEC	BAG1 →	+0.352	+1.938	.005	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 973 associations by consensus.

RAP1BL by ITGB5 expression — SKCM

Explore this box plot interactively →