ITGB5

Across TCGA pan-cancer cohorts, ITGB5 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ITGB5’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ITGB5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ITGB5 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

HNSC, KICH, and COAD are the cancer types where ITGB5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITGB5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.453	<.001	12	view →
KICH	Female	II,III,IV	−1.837	<.001	10	view →
COAD	Male	III,IV	+0.772	<.001	10	view →
LIHC	Female	II,III,IV	+1.623	<.001	9	view →
LUAD	All	II,III,IV	+0.660	<.001	7	view →
STAD	Male	II,III,IV	+0.945	.008	6	view →
THCA	All	All	+0.454	<.001	6	view →
LUSC	All	All	+0.812	<.001	5	view →
CHOL	All	All	+2.451	<.001	3	view →
BRCA	All	IV	+1.009	.048	2	view →
KIRP	Male	All	−0.601	.001	2	view →
READ	Male	All	+0.469	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ITGB5–HNSC

Open the HNSC breakdown →