ITGB5

Across TCGA cell cohorts, ITGB5 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITGB5-associated genes across cancer lineages are OR2M4, PRR23C, and OR2B3. Each is linked with ITGB5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITGB5-to-partner and partner-to-ITGB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2M4 grouped by ITGB5-low versus ITGB5-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB5→partner) and Y-score (partner→ITGB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OR2M4 →	+0.318	+4.044	<.001	.001	3	2
UPPER_AERODIGESTIVE_TRACT	PRR23C →	+0.006	+4.736	<.001	.009	3	2
CNS	OR2B3 →	+0.029	+4.321	<.001	.009	3	2
LARGE_INTESTINE	GABRG1 →	+0.009	+3.196	.001	.007	3	2
LUNG_NSCLC_LUAD	KRTAP10-5 →	+0.011	+4.078	<.001	.009	3	2
OESOPHAGUS	KCNA6 →	+0.036	+3.857	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

OR2M4 by ITGB5 expression — URINARY_TRACT

Explore this box plot interactively →