ITGB3

Across TCGA patient cohorts, ITGB3 mutation is significantly associated with the RNA expression of many other genes, with 4,798 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGB3-associated genes across cancer lineages are AUNIP, LINC02420, and RCC1. Each is linked with ITGB3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ITGB3-to-partner and partner-to-ITGB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AUNIP grouped by ITGB3-low versus ITGB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB3→partner) and Y-score (partner→ITGB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AUNIP →	+0.490	+1.785	.001	.001	3	4
LIHC	LINC02420 →	+0.050	+4.544	.001	.009	3	3
UCEC	RCC1 →	+0.384	+1.986	<.001	<.001	3	3
UCEC	ZFP3 →	-0.632	-2.078	<.001	<.001	3	3
SKCM	RPL23AP82 →	+0.578	+2.198	<.001	.001	3	3
UCEC	JPT1 →	+0.335	+2.180	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,798 associations by consensus.

AUNIP by ITGB3 expression — UCEC

Explore this box plot interactively →