ITGB1BP2

Across TCGA patient cohorts, ITGB1BP2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGB1BP2-associated genes across cancer lineages are GAPDH, PCNA, and PDCD4. Each is linked with ITGB1BP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITGB1BP2-to-partner and partner-to-ITGB1BP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by ITGB1BP2-low versus ITGB1BP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB1BP2→partner) and Y-score (partner→ITGB1BP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.424	+2.999	.049	.035	3	2
UCEC	PCNA →	+0.341	+2.415	<.001	.003	3	2
UCEC	PDCD4 →	-0.577	-2.321	.002	.033	3	2
UCEC	eEF2 →	+0.458	+3.459	.001	.005	3	1
UCEC	EGFR_pY1068 →	-0.279	-3.459	.005	.005	3	1
UCEC	A-Raf_pS299 →	-0.160	-2.459	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

GAPDH by ITGB1BP2 expression — UCEC

Explore this box plot interactively →