ITGB1BP1

Across TCGA patient cohorts, ITGB1BP1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGB1BP1-associated genes across cancer lineages are ERK2, MSH6, and p70-S6K_pT389. Each is linked with ITGB1BP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITGB1BP1-to-partner and partner-to-ITGB1BP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ITGB1BP1-low versus ITGB1BP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB1BP1→partner) and Y-score (partner→ITGB1BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.278	+3.169	.008	.020	3	1
UCEC	MSH6 →	-0.374	-3.169	.039	.020	3	1
UCEC	p70-S6K_pT389 →	-0.286	-2.999	.006	.035	3	1
UCEC	VHL →	-0.747	-3.000	.045	.036	3	1
UCEC	Annexin-1 →	+0.961	+3.169	<.001	.020	2	1
UCEC	EGFR_pY1068 →	-0.443	-3.169	.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

ERK2 by ITGB1BP1 expression — UCEC

Explore this box plot interactively →