ITGB1BP1

Across TCGA pan-cancer cohorts, ITGB1BP1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ITGB1BP1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ITGB1BP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ITGB1BP1 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

HNSC, LIHC, and COAD are the cancer types where ITGB1BP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITGB1BP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.328	<.001	12	view →
LIHC	Female	II,III,IV	+1.334	<.001	9	view →
COAD	Female	II,III,IV	+0.842	<.001	9	view →
LUSC	All	II,III,IV	+0.450	<.001	7	view →
KICH	Male	All	−1.542	<.001	6	view →
BRCA	All	II,III,IV	−0.919	<.001	6	view →
UCEC	All	All	−0.720	<.001	6	view →
CHOL	All	All	+2.171	<.001	5	view →
KIRC	Male	II,III,IV	−0.562	.001	4	view →
READ	Male	All	+0.733	.013	2	view →
KIRP	Male	All	−0.540	.012	2	view →
LUAD	Male	All	+0.285	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ITGB1BP1–HNSC

Open the HNSC breakdown →