ITGB1-DT

Across TCGA pan-cancer cohorts, ITGB1-DT RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ITGB1-DT data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ITGB1-DT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ITGB1-DT expression acts as an unfavorable survival marker, although some lineages such as UCS and READ show a favorable association.

KIRC, LUAD, and COAD are the cancer types where ITGB1-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.536	0.721	<.001	152	view →
LUAD	OS	Median	All	0.291	0.416	<.001	120	view →
COAD	DFS	Quartile	All	0.623	0.796	.001	103	view →
HNSC	DFS	Quartile	All	0.613	0.777	<.001	93	view →
STAD	OS	Quartile	All	0.347	0.750	<.001	90	view →
LUSC	DFS	Tertile	II,III,IV	0.474	0.675	<.001	83	view →
ACC	DFS	Median	All	0.242	0.612	<.001	70	view →
KIRP	DFS	Quartile	All	0.468	0.725	.001	61	view →
LIHC	DFS	Median	All	0.203	0.363	.001	59	view →
MESO	OS	Tertile	All	0.262	0.534	<.001	51	view →
BLCA	DFS	Median	III,IV	0.375	0.584	.010	24	view →
UCS	OS	Tertile	IV	0.898	0.358	.036	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ITGB1-DT–KIRC (OS)

Open the KIRC breakdown →