ITGB1-DT

Across TCGA pan-cancer cohorts, ITGB1-DT RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ITGB1-DT’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ITGB1-DT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ITGB1-DT is over-expressed in tumor, although a few such as PAAD and KICH show the opposite, repressed pattern.

HNSC, LUAD, and COAD are the cancer types where ITGB1-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITGB1-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.062	<.001	12	view →
LUAD	Male	III,IV	+1.635	<.001	8	view →
COAD	Female	II,III,IV	+0.430	<.001	8	view →
KIRC	Male	III,IV	+0.418	<.001	8	view →
LIHC	All	II,III,IV	+0.782	.002	7	view →
KIRP	All	All	+0.540	.008	6	view →
LUSC	Male	All	+0.441	<.001	5	view →
STAD	All	All	+0.351	.002	4	view →
ESCA	All	All	+0.488	.003	3	view →
CHOL	All	All	+2.931	<.001	2	view →
PAAD	Male	All	−0.895	.037	2	view →
KICH	Female	All	−0.294	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ITGB1-DT–HNSC

Open the HNSC breakdown →