ITGAV

Across TCGA patient cohorts, ITGAV mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGAV-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and PKC-delta_pS664. Each is linked with ITGAV in more than 2 cancer types. Because this analysis shows association rather than direction, both ITGAV-to-partner and partner-to-ITGAV results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ITGAV-low versus ITGAV-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGAV→partner) and Y-score (partner→ITGAV) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	Caspase-7-cleavedD198 →	+0.662	+3.321	.023	.010	3	3
UCEC	eIF4E →	+0.203	+2.713	.001	.003	3	3
UCEC	PKC-delta_pS664 →	-0.095	-1.906	.010	.014	3	3
UCEC	ASNS →	+0.308	+1.201	.006	.028	3	3
UCEC	4E-BP1 →	+0.288	+3.906	<.001	<.001	3	3
STAD	GSK3-a-b →	+0.180	+2.190	.020	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Caspase-7-cleavedD198 by ITGAV expression — BLCA

Explore this box plot interactively →