ITGAV

Across TCGA pan-cancer cohorts, ITGAV RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ITGAV’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ITGAV RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ITGAV is over-expressed in tumor, although a few such as UCEC and KICH show the opposite, repressed pattern.

HNSC, LIHC, and LUAD are the cancer types where ITGAV tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITGAV RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+2.437	<.001	11	view →
LIHC	Female	II,III,IV	+1.447	<.001	9	view →
LUAD	Male	II,III,IV	+1.366	<.001	8	view →
UCEC	All	All	−1.326	<.001	6	view →
BLCA	Female	All	+1.020	.002	6	view →
BRCA	Female	II,III,IV	+0.532	<.001	6	view →
LUSC	Male	All	+1.033	<.001	5	view →
KICH	All	All	−1.009	<.001	5	view →
STAD	Male	II,III,IV	+1.007	.004	5	view →
CHOL	All	All	+3.066	<.001	3	view →
ESCA	All	All	+1.219	.001	3	view →
COAD	Male	II,III,IV	+0.516	.007	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ITGAV–HNSC

Open the HNSC breakdown →