ITGAM

Across TCGA pan-cancer cohorts, ITGAM Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ITGAM data layer compared with 27 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ITGAM Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ITGAM expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, ESCA, and LUAD are the cancer types where ITGAM Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.603	<.001	36	view →
ESCA	OS	Median	II,III,IV	0.130	0.703	<.001	24	view →
LUAD	OS	Median	III,IV	0.097	0.669	<.001	24	view →
LUSC	DFS	Median	III,IV	0.209	0.558	.019	10	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ITGAM–UCEC (DFS)

Open the UCEC breakdown →