ITGAM

Across TCGA pan-cancer cohorts, ITGAM RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ITGAM’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ITGAM RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ITGAM is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, KIRP, and HNSC are the cancer types where ITGAM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITGAM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+2.106	<.001	12	view →
KIRP	Female	All	+1.532	<.001	11	view →
HNSC	Female	II,III,IV	+1.209	<.001	11	view →
THCA	Male	II,III,IV	+1.445	<.001	9	view →
LUAD	All	All	−0.759	<.001	7	view →
LUSC	Male	All	−1.693	<.001	6	view →
LIHC	All	II,III,IV	+1.053	.001	6	view →
STAD	All	All	+0.909	.002	5	view →
BRCA	Female	All	+0.375	.004	4	view →
CHOL	All	All	+2.381	<.001	3	view →
UCEC	All	All	−0.712	.001	2	view →
ESCA	All	All	+1.154	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ITGAM–KIRC

Open the KIRC breakdown →