ITGAM

Across TCGA pan-cancer cohorts, ITGAM mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ITGAM data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ITGAM mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ITGAM expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

COAD, CCRCC, and LUAD are the cancer types where ITGAM mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	II,III,IV	0.818	1.000	.026	54	view →
CCRCC	DFS	Median	III,IV	0.399	0.932	.022	13	view →
LUAD	OS	Quartile	All	0.928	1.000	.019	7	view →
HNSC	DFS	Quartile	III,IV	0.669	0.941	.027	6	view →
PDAC	OS	Quartile	II,III,IV	0.592	0.925	.031	4	view →
UCEC	OS	Median	II,III,IV	1.000	0.647	.017	4	view →
LSCC	OS	Median	All	0.875	0.736	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ITGAM–COAD (DFS)

Open the COAD breakdown →