ITGAM

Across TCGA patient cohorts, ITGAM protein abundance is significantly associated with the RNA expression of many other genes, with 19,073 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ITGAM-associated genes across cancer lineages are SIRPB1, MEFV, and PLAUR. Each is linked with ITGAM in more than 9 cancer types. Because this analysis shows association rather than direction, both ITGAM-to-partner and partner-to-ITGAM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ITGAM versus SIRPB1 in OV, with a Pearson correlation of 0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGAM→partner) and Y-score (partner→ITGAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SIRPB1 →	+0.655	+0.608	<.001	<.001	3	10
LSCC	MEFV →	+0.930	+0.801	<.001	<.001	3	10
GBM	PLAUR →	+1.452	+0.724	<.001	<.001	3	10
GBM	PLEK →	+1.270	+0.893	<.001	<.001	3	10
HNSC	G0S2 →	+2.148	+0.617	<.001	<.001	3	10
GBM	TREM1 →	+1.876	+0.890	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,073 associations by consensus.

ITGAM vs SIRPB1 — OV

Explore this scatter interactively →