ITGAM

Across TCGA patient cohorts, ITGAM protein abundance is significantly associated with the protein abundance of many other proteins, with 28,027 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ITGAM-associated proteins across cancer lineages are ACAP1, ARHGAP9, and ITGAL. Each is linked with ITGAM in more than 9 cancer types. Because this analysis shows association rather than direction, both ITGAM-to-partner and partner-to-ITGAM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ITGAM versus ACAP1 in GBM, with a Pearson correlation of 0.62.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGAM→partner) and Y-score (partner→ITGAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ACAP1 →	+0.836	+0.802	<.001	<.001	3	10
GBM	ARHGAP9 →	+0.733	+0.972	<.001	<.001	3	10
BRCA	ITGAL →	+0.643	+0.475	<.001	<.001	3	10
GBM	APBB1IP →	+0.655	+0.672	<.001	<.001	3	10
GBM	ALOX5 →	+1.048	+1.040	<.001	<.001	3	10
GBM	HCK →	+0.889	+1.003	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 28,027 associations by consensus.

ITGAM vs ACAP1 — GBM

Explore this scatter interactively →