ITGAM

Across TCGA patient cohorts, ITGAM mutation is significantly associated with the RNA expression of many other genes, with 4,999 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGAM-associated genes across cancer lineages are PRIM1, DCLRE1A, and GMNN. Each is linked with ITGAM in more than 3 cancer types. Because this analysis shows association rather than direction, both ITGAM-to-partner and partner-to-ITGAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRIM1 grouped by ITGAM-low versus ITGAM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGAM→partner) and Y-score (partner→ITGAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRIM1 →	+0.701	+2.071	<.001	<.001	3	4
SKCM	DCLRE1A →	+0.457	+2.096	.008	.003	3	4
UCEC	GMNN →	+0.582	+1.869	<.001	<.001	3	4
UCEC	CENPL →	+0.363	+2.102	.001	<.001	3	4
LUAD	GLO1 →	+0.440	+2.608	.003	<.001	3	4
UCEC	CTDSPL2 →	+0.407	+1.545	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,999 associations by consensus.

PRIM1 by ITGAM expression — UCEC

Explore this box plot interactively →