ITGAM

Across TCGA patient cohorts, ITGAM mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGAM-associated genes across cancer lineages are eIF4E, ATM, and MEK1. Each is linked with ITGAM in more than 3 cancer types. Because this analysis shows association rather than direction, both ITGAM-to-partner and partner-to-ITGAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ITGAM-low versus ITGAM-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGAM→partner) and Y-score (partner→ITGAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.236	+2.484	.002	.010	3	4
UCEC	ATM →	-0.566	-2.000	<.001	<.001	3	4
UCEC	MEK1 →	+0.468	+2.000	<.001	<.001	3	3
UCEC	Notch1 →	+0.121	+1.515	.002	.015	3	3
UCEC	Caspase-7-cleavedD198 →	+0.433	+1.604	.010	.005	3	3
SKCM	c-Myc →	-0.323	-3.169	.015	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

eIF4E by ITGAM expression — COAD

Explore this box plot interactively →