ITGAM

Across TCGA cell cohorts, ITGAM RNA expression is significantly associated with the go_rna of many other GO terms, with 3,441 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ITGAM-associated GO terms across cancer lineages are Positive regulation of microglial cell mediated cytotoxicity, Regulation of microglial cell mediated cytotoxicity, and Canonical NF-kappaB signal transduction. Each is linked with ITGAM in more than 14 cancer types. Because this analysis shows association rather than direction, both ITGAM-to-partner and partner-to-ITGAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of microglial cell mediated cytotoxicity grouped by ITGAM-low versus ITGAM-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGAM→partner) and Y-score (partner→ITGAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Positive regulation of microglial cell mediated cytotoxicity →	+0.596	+1.807	.004	.001	3	15
BLOOD_Leukemia	Regulation of microglial cell mediated cytotoxicity →	+0.585	+1.719	.006	.002	3	14
KIDNEY	Canonical NF-kappaB signal transduction →	+0.091	+1.005	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Regulation of pattern recognition receptor signaling pathway →	+0.059	+0.414	<.001	<.001	3	9
OESOPHAGUS	Negative regulation of dopamine metabolic process →	-0.430	-0.976	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	mRNA transcription →	+0.077	+0.425	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,441 associations by consensus.

Positive regulation of microglial cell mediated cytotoxicity by ITGAM expression — BLOOD_Leukemia

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