ITGAM

Across TCGA cell cohorts, ITGAM mutation is significantly associated with the RNA expression of many other genes, with 138 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITGAM-associated genes across cancer lineages are CD300H, APOC4, and PGM3. Each is linked with ITGAM in more than 1 cancer types. Because this analysis shows association rather than direction, both ITGAM-to-partner and partner-to-ITGAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD300H grouped by ITGAM-low versus ITGAM-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGAM→partner) and Y-score (partner→ITGAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CD300H →	+0.116	+3.584	<.001	.003	3	2
LUNG_NSCLC_LUAD	APOC4 →	+0.028	+3.944	<.001	.006	3	2
LARGE_INTESTINE	PGM3 →	+0.752	+2.502	.004	.005	3	2
LARGE_INTESTINE	CEPT1 →	+0.532	+3.087	<.001	.006	3	2
LARGE_INTESTINE	BCL10 →	+0.469	+3.321	.002	.003	3	2
LARGE_INTESTINE	ABCE1 →	+0.656	+2.502	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 138 associations by consensus.

CD300H by ITGAM expression — LUNG_SCLC

Explore this box plot interactively →